NR AOXF
AU Murdoch,H.; Taylor,D.N.; Dickinson,J.; Hall,G.A.; Dennis,M.J.; Lelean,J.A.; Bumpass,D.C.; Kirby,E.R.; Sutton,J.M.; Raven,N.D.H.
TI Characterisation of novel isoforms of the prion protein and the development of therapeutic approaches to treatment of TSE diseases
QU International Conference - Prion diseases: from basic research to intervention concepts - TSE-Forum, 08.10.-10.10.2003, Gasteig, München - Poster session - IV-19
PT Konferenz-Poster
AB
Creutzfeldt-Jakob Disease (CJD) is a relatively rare form of human dementia presenting as a familial, sporadic or iatrogenic disease. The disorder is part of a family of related diseases, the Transmissable Spongiform Encephalopathies (TSEs), characterised by a progressive and invariably fatal neurodegeneration associated typically with a spongiform brain pathology at post-mortem. The emergence of a variant form of the disease (vCJD) presenting in younger individuals, possibly due to ingestion of prion-contaminated meat products has emphasised the need for novel therapeutic strategies.
Using a peptide immunisation strategy we have generated high titre polyclonal and monoclonal antibodies against specific domains of the prion protein. A number of these antibodies recognise a series of novel isoforms of the prion protein of 40-70 kDa specifically in infectious brain material from a BSE(301V)-VM mouse model. The precise nature of these novel isoforms is the topic of intense investigation in our laboratory. We will present data to support the hypothesis that these isoforms are relevant to the infectivity of prion proteins. As the potential of therapuetic immunisation has been well described in relation to Alzheimer's disease and has also now been described in relation to TSEs these isoforms may provide a novel target for therapeutic intervention.
AD H. Murdoch, D.N. Taylor, J. Dickinson, G.A. Hall, M.J. Dennis, J.A. Lelean, D.C. Bumpass, E.R. Kirby, J.M. Sutton, N.D.H. Raven, HPA-Porton Down, UK
SP englisch
PO Deutschland