NR AOWF
AU Majtenyi,K.
TI Creutzfeldt-Jakob Disease in old age
QU International Conference - Prion diseases: from basic research to intervention concepts - TSE-Forum, 08.10.-10.10.2003, Gasteig, München - Poster session - PG-32
PT Konferenz-Poster
AB
In the period 2000-2002 60 suspected Creutzfeldt-Jakob Disease (CJD) patients were reported to the Hungarian reference center. Detailed neuropathological and immunohistochemical examination was established in all cases. 35 proved to be CJD; in the other 25 cases CJD was a misdiagnosis.
The age of the patients was over 70 in 10 out of the 35 cases (71-76). Most of them (9) belonged to the sporadic form. In 4 of the 10 cases vascular complications were present beside the typical cortical pathology. Moreover, in one case 'pseudokalk' occured in the Ammon's horn. Cortical amyloid plaques were present in 2 cases without tau-pathology.
The most striking feature seemed to be in this age-group the participation of the hippocampal and parahippocampal cortex in the basic pathological process: severe spongiform alteration and astrocytic proliferation were observed. The participation of this area is unusual in middle aged patients. The extremely severe spongiform changes of the visual cortical area is to be mentioned as well - this fact influenced entirely the course of the clinical symptoms in this age-group.
AD Katalin Majtenyi, National Institute of Psychiatry and Neurology, Hungary
SP englisch
PO Deutschland