NR AOUH
AU Hunter,N.; Houston,E.F.; Goldmann,W.; Foster,J.
TI Pathogenesis of TSEs in sheep: experimental studies and natural disease
QU International Conference - Prion diseases: from basic research to intervention concepts - TSE-Forum, 08.10.-10.10.2003, Gasteig, München - Oral sessions OS-24
PT Konferenz-Vortrag
AB
Experimental studies of both scrapie and BSE in sheep have provided some interesting and perhaps surprising results. We have reported recently on successful transmission of both BSE and scrapie between sheep by blood transfusion. This is of importance in the debate about safety of blood products but it is also telling us something about how TSE infectivity travels through the body of an infected animal on its journey from the site of initial infection towards the central nervous system and the brain.
It is also clear that sheep regarded as resistant to infection (ARR/ARR genotype) can support infection if it is delivered by the intracerebral route. It had been suggested previously that the reason for resistance in this genotype was the inability of the ARR PrP protein allotype to convert to PrPsc, but our results have shown that this is cannot be the case.
Updates on results from both studies will be presented and the importance for understanding of TSE pathogenesis discussed.
AD N. Hunter, F. Houston, W. Goldmann, J. Foster, Institute for Animal Health, UK
SP englisch
PO Deutschland