NR AORH
AU Cepek,L.; Steinacker,P.; Brit,M.; Ciesielczyk,B.; Wiltfang,J.; Zerr,I.; Schulz-Schaeffer,W.J.; Kretzschmar,H.A.; Poser,S.; Otto,M.
TI Tau-protein levels and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob-disease
QU International Conference - Prion diseases: from basic research to intervention concepts - TSE-Forum, 08.10.-10.10.2003, Gasteig, München - Poster session - DG-51
PT Konferenz-Poster
AB
Background: S-100B and tau-protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there was only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). Especially as there is an interest in finding biochemical markers to monitor disease progression for differential diagnostic reasons and for therapeutic trials.
Patients and methods: We analysed CSF of 45 patients with CJD and 45 patient with other neurological diseases for tau-protein and S-100B in the follow-up. All CJD patients were later neuropathologically verified. A ratio between tau-protein-differences and the time between lumbar punctures was calculated. The same was done for S-100B.
Results: Tau-protein levels of 34 cases were above the cut-off level for CJD (>1300 pg/ml) in the first CSF sample. In seven out of eleven patients with lower tau-levels in the first CSF sample tau-levels rose. The above mentioned ratio was significantly higher in the CJD group compared to group of other neurological diseases. Similar results were obtained for S-100B.
Conclusion: We conclude that follow-up investigations and calculation of ratios is a useful tool in the differential diagnosis of CJD. However for a specific case all variations of CSF pattern were observed.
AD L. Cepek, P. Steinacker, M. Brit, B. Ciesielczyk, I. Zerr, S. Poser, M. Otto, Dept. of Neurolgy, University of Göttingen, Germany; W. Schulz-Schaeffer, Dept. of Neuropathology, University of Göttingen, Germany; J. Wiltfang, Dept. of Psychiatry, University of Erlangen, Germany; H.A. Kretzschmar, Dept. of Neuropathology, University of Munich, Germany
SP englisch
PO Deutschland