NR AOLH
AU Kretzschmar,H.A.; Sethi,S.K.; Foldvari,Z.; Windl,O.; Querner,V.; Zerr,I.; Poser,S.
TI Latrogenic Creutzfeldt-Jakob disease with florid plaques
QU Brain Pathology 2003 Jul; 13(3): 245-9
PT journal article; review; review of reported cases
AB Florid plaques indistinguishable from those found in vCJD were identified at a postmortem examination in the brain of a 58-year-old clinical suspect case of Creutzfeldt-Jakob disease (CJD). Western blotting of brain tissue revealed an unusual prion protein type. Since the patient had received a dura mater graft 20 years prior to death and florid plaques are not only found in new variant CJD, the findings argue in favor of an iatrogenic origin of the disease with the longest incubation time following a dura mater graft reported to date even though he may have been exposed to BSE. The peculiar pathological, clinical and biochemical features may define a new type of human prion disease.
ZR 15
MH Aged; Amyloid/genetics/metabolism; Blotting, Western/methods; Case Report; Cerebral Cortex/drug effects/*pathology; Creutzfeldt-Jakob Syndrome/*complications/genetics/pathology/surgery; Dura Mater/transplantation; Endopeptidase K/pharmacology; Female; Human; Lectins, C-Type/metabolism; Male; Middle Age; PrPsc Proteins/metabolism; Protein Precursors/genetics/metabolism; Receptors, Cell Surface/metabolism; Support, Non-U.S. Gov't
AD Institut für Neuropathologie, Ludwig-Maximilians-Universität München, Germany. Hans.Kretzschmar@inp.med.uni-muenchen.de
SP englisch
PO Schweiz