NR AOHY
AU Wiltfang,J.; Esselmann,H.; Smirnov,A.; Bibl,M.; Cepek,L.; Steinacker,P.; Mollenhauer,B.; Bürger,K.; Hampel,H.; Paul,S.; Neumann,M.; Maler,M.; Zerr,I.; Kornhuber,J.; Kretzschmar,H.A.; Poser,S.; Otto,M.
TI ß-Amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
QU Annals of Neurology 2003 Aug; 54(2): 263-7
PT journal article
AB Decreased levels of beta-amyloid peptide 1-42 (Aß1-42) in cerebrospinal fluid (CSF) are a characteristic feature of Alzheimer's disease (AD) but recently were also observed in Creutzfeldt-Jakob disease (CJD). We analyzed the CSF of patients with CJD, and AD and nondemented controls using a quantitative urea-based Aß sodium dodecyl sulfate polyacrylamide gel electrophoresis immunoblot. Like in AD and nondemented controls, we found a highly conserved pattern of carboxyterminally truncated Aß1-37/38/39 in addition to Abeta1-40/42 also in CJD patients. By the introduction of the ratio Aß1-39 to Aß1-42, CJD and AD can effectively be differentiated. We conclude that the immunoblot shows disease-specific CSF Aß peptide patterns in CJD and AD and suppose that measurement of the Aß peptide pattern seems to be a promising diagnostic tool in the differential diagnosis of dementias.
MH Adult; Aged; Aged, 80 and over; Alzheimer Disease/cerebrospinal fluid; Amyloid beta-Protein/*cerebrospinal fluid; Apolipoproteins E/cerebrospinal fluid; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid; Electrophoresis, Polyacrylamide Gel; Encephalitis/cerebrospinal fluid; Female; Human; Immunoblotting; Male; Middle Aged; Peptide Fragments/cerebrospinal fluid; Support, Non-U.S. Gov't; tau Proteins/cerebrospinal fluid
AD Department of Psychiatry, University Erlangen-Nürnberg, Germany.
SP englisch
PO USA