NR AOCA

AU Bergui,M.; Bradac,G.B.; Rossi,G.; Orsi,L.

TI Extensive cortical damage in a case of Creutzfeldt-Jakob disease: clinicoradiological correlations.

QU Neuroradiology 2003 May; 45(5): 304-7

PT journal article

AB MRI demonstrated extensive cortical involvement in a patient with pathologically proven Creutzfeldt-Jakob disease. The whole brain was atrophic; some of the supratentorial cortex, putamen and caudate nucleus gave high signal on T2-weighted images; the changes were more extensive on diffusion-weighted images (DWI). Comparison of the history, and the sites of atrophy and signal change suggested that the latter predominates in regions with long-lasting damage and prevalent gliosis, while high signal on DWI indicate current neuronal loss. This case widens the range of MRI findings in patients with Creutzfeldt-Jakob disease, and suggests that some information about the progression of the disease can be extracted from single MRI study.

MH Brain/*pathology; Case Report; Cerebral Cortex/pathology; Creutzfeldt-Jakob Syndrome/*pathology; *Diffusion Magnetic Resonance Imaging; Disease Progression; Human; Male; Middle Age

AD Neuroradiology, Ospedale S. G. Battista, University of Torino, Via Cherasco 15, 10126 Torino, Italy.

SP englisch

PO Deutschland

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