NR AOBZ
AU Comoy,E.E.; Bonnevalle,C.; Metais,A.; Auvre,F.; Letessier,F.; Lamoury,F.; Spittler,J.; Dormont,D.; Deslys,J.P.
TI [Disinfection of gas-permeable contact lenses against prions]
OT Desinfection de lentilles de contact rigides permeables vis-a-vis des prions
QU Journal Francais d'Ophtalmologie 2003 Mar; 26(3): 233-9
PT journal article
AB Potential iatrogenic transmission from patients incubating Creutzfeldt-Jakob disease, especially variant CJD, is a major public health issue. Because the ocular route is very efficient for contamination with prions, re-use of rigid contact lenses in ophthalmology constitutes a potential problem. We therefore evaluated the anti-prion activity of different protocols available for disinfection of lenses. These treatments decreased the infectivity retained on the surface of experimentally contaminated lenses by a factor of at least 10 million. They thus represent an important factor in protecting against possible prion infection via the ocular route.
MH Animal; *Contact Lenses, Hydrophilic; Disinfection/*methods; English Abstract; Female; Hamsters; Human; Mesocricetus; Models, Animal; Permeability; Prion Diseases/*prevention & control/transmission; Prions/isolation & purification/*pathogenicity
AD Departement de Recherche Medicale/Direction des Sciences du Vivant, CEA, Fontenay-aux-Roses Cedex. comoy@dsvidf.cea.fr
SP französisch
PO Frankreich