NR ANYH
AU Kornblatt,J.A.; Marchal,S.; Rezaei,H.; Kornblatt,M.J.; Balny,C.; Lange,R.; Debey,M.P.; Hui Bon Hoa,G.; Marden,M.C.; Grosclaude,J.
TI The fate of the prion protein in the prion/plasminogen complex
QU Biochemical and Biophysical Research Communications 2003 Jun 6; 305(3): 518-22
PT journal article
AB The cellular prion protein (PrPc) forms complexes with plasminogen. Here, we show that the PrPc in this complex is cleaved to yield fragments of PrPc. The cleavage is accelerated by plasmin but does not appear to be dependent on it.
MH Animal; Electrophoresis, Polyacrylamide Gel; Human; Macromolecular Systems; Peptide Fragments/metabolism; Plasmin/metabolism; Plasminogen/*metabolism; PrPc Proteins/*metabolism; Sheep; Support, Non-U.S. Gov't; Tissue Plasminogen Activator/metabolism
AD Concordia University, 1455 de Maisonneuve Blvd., Montreal, Qc, Canada H3G 1M8. krnbltt@vax2.concordia.ca
SP englisch
PO USA