NR ANSE
AU Pandya,H.G.; Coley,S.C.; Wilkinson,I.D.; Griffiths,P.D.
TI Magnetic resonance spectroscopic abnormalities in sporadic and variant Creutzfeldt-Jakob disease
QU Clinical Radiology 2003 Feb; 58(2): 148-53
PT journal article
AB AIM: To study the proton MR spectroscopic findings in Creutzfeldt-Jakob disease (CJD) (sporadic and variant). MATERIALS AND METHODS: MR imaging and proton MR spectra were acquired in two patients with sporadic CJD (biopsy proven) and one patient with variant CJD. RESULTS: The two patients with sporadic CJD demonstrated MR signal change within the basal ganglia and thalami and reduced N-acetylaspartate (NAA):creatine ratios. The patient with variant CJD showed characteristic signal change within the pulvinar of the thalami and a markedly reduced N-acetylaspartate:creatine ratio. CONCLUSION: All three patients with CJD demonstrated evidence of reduced N-acetylaspartate: creatine ratios on MR spectroscopy. These changes imply that neuronal loss and/or dysfunction is a consistent finding in established CJD.
MH Adult; Aged; Aspartic Acid/*analogs & derivatives/*metabolism; Basal Ganglia/metabolism; Case Report; Creatine/metabolism; Creutzfeldt-Jakob Syndrome/*diagnosis/metabolism; Fatal Outcome; Female; Human; Magnetic Resonance Imaging; *Magnetic Resonance Spectroscopy; Thalamus/metabolism
AD Section of Academic Radiology, Royal Hallamshire Hospital, Floor C Glossop Road, Sheffield, UK. Hament@doctors.org.uk
SP englisch
PO England