NR ANPY
AU Dermaut,B.; Croes,E.A.; Rademakers,R.; van den Broeck,M.; Cruts,M.; Hofman,A.; van Duijn,C.M.; van Broeckhoven,C.
TI PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
QU Annals of Neurology 2003 Mar; 53(3): 409-12
PT journal article
AB We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.
IN In den Niederlanden scheinen Alzheimer-Patienten im Durchschnitt früher erkrankt zu sein, wenn sie hinsichtlich des Codons 129 des Prionproteingens homozygot waren. Besonders stark war dieser Effekt bei den Valin-Homozygoten.
MH Adult; Aged; Alleles; Alzheimer Disease/*genetics; Amyloid/*genetics; Chi-Square Distribution; Comparative Study; Confidence Intervals; Female; Genotype; *Homozygote; Human; Male; Middle Age; Odds Ratio; Prions/*genetics; Protein Precursors/*genetics; Risk Factors; Support, Non-U.S. Gov't
AD Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology (VIB8), University of Antwerp, Antwerpen, Belgium.
SP englisch
PO USA