NR ANMK
AU Ishida,C.; Kakishima,A.; Okino,S.; Furukawa,Y.; Kano,M.; Oda,Y.; Nakanishi,I.; Makifuchi,T.; Kitamoto,T.; Yamada,M.
TI Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques
QU Neurology 2003 Feb 11; 60(3): 514-7
PT journal article
AB The authors report a 75-year-old woman with atypical sporadic Creutzfeldt-Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft-associated CJD or shared host genetic factors that are unrelated to the PrP genotype.
MH Aged; Blotting, Western; Brain/pathology; Brain Chemistry; Case Report; Cerebrospinal Fluid Proteins/analysis; Creutzfeldt-Jakob Syndrome/complications/*diagnosis/pathology; Electroencephalography; Female; Gliosis/etiology/pathology; Human; Immunohistochemistry; Inappropriate ADH Syndrome/complications/diagnosis; Magnetic Resonance Imaging; Prions/*analysis/genetics; Senile Plaques/*pathology; Support, Non-U.S. Gov't
AD Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Ishikawa 920-8640, Japan. cishida@noto-hospital.jp
SP englisch
PO USA