NR ANLI
AU Numao,N.; Noguchi,N.; Eguchi,Y.; Watanabe,S.; Fukui,T.; Kamino,T.; Shimozono,N.; Yamazaki,A.; Kobayashi,S.; Sasatsu,M.
TI Novel biological activity of the region (106-126) on human prion sequence
QU Biological and Pharmaceutical Bulletin 2003 Feb; 26(2): 229-32
PT journal article
AB We report that the synthetic peptide Prp106-126 (KTNMKHMAGAAAAGAVVGGLG-COOH) and the reversed peptide Prp126-106 (GLGGVVAGAAAAGAMHKMNTK-COOH) of human prion (hPrp) can express the decarboxylase activity for oxaloacetate in the presence of trifluoroethanol, similar to that of Oxaldie 1 (LAKLLKALAKLLKK-CONH(2)) reported previously. The degree of the relative activity of Prp106-126 and Prp126-106 to Oxaldie 1 is 0.47 and 0.21, respectively. Based on this experimental result, we applied the informational system method (ISM) developed by Veljkovic et al. to the amino acid sequence of Prp106-126 and Prp126-106 to extract a common factor. The same spectra were obtained, indicating that the same periodicity may be conserved on their sequences, as a necessary factor for expressing the same biological activity, irrespective of the orientation of the primary sequence.
AD BioFrontier Institute Inc.
SP englisch
PO Japan