NR AMYF
AU Zavalishin,I.A.; Pogodina,V.V.; Roikhel',V.M.; Fokina,G.I.; Niiazbekova,A.S.
TI [Anti-neurofilament antibodies in slow infections of the nervous system]
OT Antitela k neirofilamentam pri medlennykh infektsiiakh nervnoi sistemy
QU Zhurnal Nevropatologii i Psikhiatrii Imeni S. S. Korsakova 1988; 88(2): 11-6
PT journal article
AB Twenty-six patients including 12 with lateral amyotrophic sclerosis, 7 with multiple sclerosis, 5 with the Creutzfeldt-Jakob disease and 2 with Alzheimer's disease were examined. Antibodies to neurofilaments in the blood serum were detected in all cases of the Creutzfeldt-Jakob disease and Alzheimer's disease and in 8 patients with lateral amyotrophic sclerosis with clinical evidence of supranuclear structure involvement. A conclusion is drawn about a certain similarity of pathogenic mechanisms of these diseases, as well as about heterogeneity of the cytoskeleton of neurons in the brain and the spinal cord.
MH Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis/etiology/immunology; Animal; Antibodies, Viral/analysis; Autoantibodies/*analysis; Brain/*immunology/ultrastructure; Cytoskeleton/*immunology; English Abstract; Female; Human; Intermediate Filaments/*immunology; Male; Mice; Mice, Inbred BALB C; Middle Age; Multiple Sclerosis/etiology/immunology; Slow Virus Diseases/*immunology; Spinal Cord/*immunology/ultrastructure
SP russisch
PO Sowjetunion