NR AMWZ
AU Yu,R.K.; Manuelidis,E.E.
TI Ganglioside alterations in guinea pig brains at end stages of experimental Creutzfeldt-Jakob disease
QU Journal of the Neurological Sciences 1978 Jan; 35(1): 15-23
PT journal article
AB Gangliosides were isolated from guinea pig brains at the end stages of experimental Creutzfeldt-Jakob disease. Quantitative analyses revealed marked decreases of ganglioside levels in pathologically devastated tissues such as cerebral cortex (-21%), basal ganglia and thalamus (-18%), and brain stem (-23%). The cerebellum revealed only minor pathological abnormalities and its ganglioside level remained unchanged. Thin-layer chromatography of the Creutzfeldt-Jakob brain gangliosides showed aberrant ganglioside patterns in all regions studied, including the cerebellum. With some exceptions, a trend in ganglioside pattern changes was detected which consisted of proliferation of GM3, GD3, GD2 and loss of GM1, GD1a, GD1b and GT1b.
MH Animal; Basal Ganglia/metabolism; Brain/*metabolism; Brain Stem/metabolism; Cerebellum/metabolism; Cerebral Cortex/metabolism; Creutzfeldt-Jakob Syndrome/*metabolism; Disease Models, Animal; Gangliosides/analysis/*metabolism; Guinea Pigs; Human; Support, U.S. Gov't, P.H.S.; Thalamus/metabolism
SP englisch
PO Niederlande