NR AMOZ
AU Williams,A.E.; van Dam,A.M.; Man-A-Hing,W.K.H.; Berkenbosch,F.; Eikelenboom,P.; Fraser,H.
TI Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice
QU Brain Research 1994 Aug 22; 654(2): 200-6
PT journal article
AB The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1 beta, tumour necrosis factor alpha, prostaglandin E2, prostaglandin F2 alpha and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.
IN Scrapie-Infektionen scheinen in Mausgehirnen die Expression von glialem Interleukin-1 beta, Tumornekrosefaktor alpha, Prostaglandin E(2), Prostaglandin F-2 alpha und Lipocortin-1 vermutlich durch Astrozyten zu verstärken.
ZR 57
MH Animal; Annexin I/analysis/*metabolism; Antibodies; Antigens, Differentiation/metabolism; Astrocytes/metabolism/pathology; Brain/*metabolism/pathology; Comparative Study; Cytokines/analysis/*metabolism; Dinoprost/metabolism; Dinoprostone/metabolism; Glial Fibrillary Acidic Protein/analysis/metabolism; Interleukin-1/metabolism; Mice; Mice, Inbred Strains; Neuroglia/metabolism/pathology; PrPsc Proteins; Prostaglandins/analysis/*metabolism; Reference Values; Scrapie/*metabolism/pathology; Tumor Necrosis Factor/metabolism; Vacuoles/pathology
AD BBSRC and MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, UK
SP englisch
PO Niederlande