NR AMKE
AU Westaway,D.; Goodman,P.A.; Mirenda,C.A.; McKinley,M.P.; Carlson,G.A.; Prusiner,S.B.
TI Distinct prion proteins in short and long scrapie incubation period mice
QU Cell 1987 Nov 20; 51(4): 651-62
PT journal article
AB The Prn-i gene, controlling scrapie incubation period, is linked to or congruent with the murine prion protein (PrP) gene, Prn-p. In prototypic mouse strains with long (l/Ln) and short (NZW) incubation periods, Prn-p transcription is initiated at similar multiple sites. The predicted NZW and l/Ln PrP proteins differ at codons 108 and 189. Codon 189, highly conserved in mammals, lies within a polymorphic BstEll site that is retained in 17 mouse strains known to have short or intermediate incubation times, but is absent in l/Ln and two other inbred mice with long incubation times. Codon 108 in mice with short or intermediate incubation times encodes Leu; in mice with long incubation times it encodes Phe. The correlation of PrP sequence with length of scrapie incubation period suggests, but does not formally prove, congruency between Prn-p and Prn-i.
MH Amino Acid Sequence; Animal; Base Sequence; Codon; Comparative Study; Disease Susceptibility; Mice; Mice, Inbred Strains; Molecular Sequence Data; Polymorphism (Genetics); PrP 27-30 Protein; Prions/*genetics; Scrapie/*etiology/physiopathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Time Factors; Viral Proteins/*genetics
AD Department of Neurology, University of California, San Francisco 94143.
SP englisch
PO USA