NR AMBU
AU Voigtländer,T.; Klöppel,S.; Birner,P.; Jarius,C.; Flicker,H.; Verghese-Nikolakaki,S.; Sklaviadis,T.K.; Guentchev,M.; Budka,H.
TI Marked increase of neuronal prion protein immunoreactivity in Alzheimer's disease and human prion diseases
QU Acta Neuropathologica 2001 May; 101(5): 417-23
PT journal article
AB In neurodegenerative disorders including Alzheimer's disease (AD), free radical damage to lipids, carbohydrates, proteins and DNA has been demonstrated to play a key pathogenetic role. In vitro studies have suggested a function of the cellular prion protein (PrPc) in the defense against oxidative stress. Therefore, we investigated the distribution of PrPc immunoreactivity in hippocampus (sectors CA4-CA1), subiculum (Sub), entorhinal (EC), and temporal cortex (TC) in sections from AD, human transmissible spongiform encephalopathy (TSE) and control brains. Compared to control cases, AD brains revealed an increase in the proportion of PrPc-immunoreactive neurons, which was statistically significant in CA2, Sub, and TC. In TSEs, a statistically significant increase of PrPc-immunoreactive neurons was observed in CA2, CA1, Sub, EC, and TC. In conclusion, our data show a striking up-regulation of PrPc in neurodegeneration and provide additional support for the concept that PrPc may be involved in the defense against oxidative stress.
MH Adult; Aged; Aged, 80 and over; Alzheimer Disease/*pathology/physiopathology; Brain/*pathology/physiopathology; Cell Count; Female; Human; Immunohistochemistry; Male; Middle Age; Neurons/*pathology; Oxidative Stress/*physiology; PrPc Proteins/*analysis; Prion Diseases/*pathology/physiopathology; Support, Non-U.S. Gov't; Up-Regulation/*physiology
AD Institute of Neurology, University of Vienna, Wien, Austria.
SP englisch
PO Deutschland