NR AMAN
AU Victoroff,J.; Ross,G.W.; Benson,D.F.; Verity,M.A.; Vinters,H.V.
TI Posterior cortical atrophy. Neuropathologic correlations.
QU Archives of Neurology 1994 Mar; 51(3): 269-74
KI Arch Neurol. 1996 Oct;53(10):958. PMID: 8859056
PT journal article
AB OBJECTIVE: A subgroup of patients with progressive dementia has been reported with a marked predominance of symptoms attributed to the dysfunction of the posterior parieto-occipital cortex. These cases have been referred to as posterior cortical atrophy. The objective of this study was to determine whether posterior cortical atrophy is associated with distinct, uniform neuropathologic findings. DESIGN: Three individuals with progressive dementia that began with higher visual dysfunction (posterior cortical atrophy) were followed up to definitive neuropathologic diagnosis. RESULTS: Three separate neuropathologic entities were discovered: subcortical gliosis, Alzheimer's disease, and Creutzfeldt-Jakob disease. CONCLUSION: Posterior cortical atrophy is a clinically homogeneous but pathologically heterogeneous syndrome.
MH Aged; Alzheimer Disease/pathology; Atrophy; Case Report; Creutzfeldt-Jakob Syndrome/pathology; Dementia/metabolism/*pathology; Gliosis/pathology; Human; Male; Middle Age; Occipital Lobe/metabolism/*pathology; Parietal Lobe/metabolism/*pathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
AD Department of Neurology, UCLA School of Medicine.
SP englisch
PO USA