NR ALWP
AU Vaccari,G.; Petraroli,R.; Agrimi,U.; Eleni,C.; Perfetti,M.G.; Di Bari,M.A.; Morelli,L.; Ligios,C.; Busani,L.; Nonno,R.; Di Guardo,G.
TI PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report.
QU Archives of Virology 2001 Oct; 146(10): 2029-37
PT journal article
AB Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks. We investigated PrP gene polymorphisms in scrapie-affected and clinically healthy Sarda breed sheep from a flock exposed to the aforementioned vaccine, and in affected Sarda sheep from unexposed flocks. All affected animals were (Gln/Gln)171 homozygous. Moreover, we observed no variation for Ala136 and a new polymorphism (Lys to Asn) at codon 176. Our findings confirm the correlation between scrapie and (Gln/Gln)171 in breeds with no variation for Ala136.
MH Animal; Base Sequence; Codon; Genetic Predisposition to Disease; Genotype; Molecular Sequence Data; Polymorphism (Genetics); Prions/*genetics; Rabbits; Scrapie/*genetics; Sheep; Support, Non-U.S. Gov't
AD Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Rome, Italy.
SP englisch
PO Österreich