NR ALWC
AU Urbach,H.; Paus,S.; Tschampa,H.J.; Keller,E.; Schild,H.H.
TI [Creutzfeldt-Jakob disease: value of MRI]
OT Creutzfeldt-Jakob-Krankheit: Stellenwert der MRT.
QU Rofo. Fortschritte auf dem Gebiete der Röntgenstrahlen und der neuen bildgebenden Verfahren 2001 Jun; 173(6): 509-14
ER Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 2001 Sep;173(9):847
PT journal article
AB PURPOSE: To define the role of MRI in the diagnosis of Creutzfeldt-Jakob disease (CJD). METHODS: 14 patients with suspected CJD were studied within 3 years. MRI findings were correlated with WHO established diagnostic criteria (clinical findings, EEG, CSF with 14-3-3 protein assay). RESULTS: 12 patients had CJD. One patient each suffered from Hashimoto's encephalitis and ALS dementia complex, respectively. Nine of 12 CJD patients had increased signal intensity of the striatum (n = 8), pulvinar thalami (n = 5) and/or cerebellar and cerebral cortex (n = 3), respectively. Signal intensity was most pronounced on FLAIR sequences; six patients were studied with diffusion-weighted MRI and showed impaired diffusion in these areas. Both patients without CJD did not show the abovementioned signal changes (sensitivity 75%, specificity and positive predictive value 100%, respectively). CONCLUSION: If patients with suspected CJD are studied with FLAIR and diffusion-weighted sequences, this disorder can reliably be proven or ruled out. Typical MRI findings narrow down the differential diagnosis and should be included in the WHO diagnostic criteria.
MH Adult; Aged; Aged, 80 and over; Brain/pathology; Creutzfeldt-Jakob Syndrome/*diagnosis; Diagnosis, Differential; English Abstract; Female; Human; *Magnetic Resonance Imaging; Male; Middle Age; Predictive Value of Tests
AD Radiologische Klinik, Rheinische Friedrich-Wilhelms-Universität Bonn. urbach@uni-bonn.de
SP deutsch
PO Deutschland