NR ALUK
AU Tuite,M.F.; Lindquist,S.L.
TI Maintenance and inheritance of yeast prions
QU Trends in Genetics 1996 Nov; 12(11): 467-71
PT journal article; review; review, tutorial
AB The unusual genetic behaviour of two yeast extrachromosomal elements [PSI] and [URE3] is entirely consistent with a prion-like mechanism of inheritance involving an autocatalytic alteration in the conformation of a normal cellular protein. In the case of both yeast determinants the identity of the underlying cellular prion protein is known. The discovery that the molecular chaperone Hsp104 is essential for the establishment and maintenance of the [PSI] determinant provides an explanation for several aspects of the puzzling genetic behaviour of these determinants. What remains to be explained is whether these determinants represent 'disease states' of yeast or represent the first examples of a unique mechanism for producing a heritable change in phenotype without an underlying change in genotype.
ZR 41
MH Fungal Proteins/*genetics; Gene Expression Regulation, Fungal; Heat-Shock Proteins/genetics/metabolism; Models, Biological; PrPc Proteins/chemistry/genetics/metabolism; PrPsc Proteins/chemistry/genetics/metabolism; Prions/*genetics/metabolism; Protein Conformation; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Yeasts/*genetics
AD Research School of Biosciences, University of Kent, Canterbury, UK. m.f.tuite@ukc.ac.uk
SP englisch
PO England