NR ALUE
AU Tsukamoto,T.; Diringer,H.; Ludwig,H.
TI Absence of autoantibodies against neurofilament proteins in the sera of scrapie infected mice
QU Tohoku Journal of Experimental Medicine 1985 Aug; 146(4): 483-4
PT journal article
AB Autoantibodies against neurofilament proteins were not detected in any of the sera from the following scrapie infected mice: 19 mice infected with scrapie agent 139A in pre-clinical stage, 32 histologically confirmed scrapie mice and other 12 clinical scrapie mice infected with various strains. The test sera were assayed against acetone-fixed central neuron cultures from fetal mice by indirect immunofluorescence and immunoperoxidase techniques. The negative result suggests that autoantibodies against neurofilament proteins do not play a role in the pathogenesis of scrapie.
MH Animal; Autoantibodies/*analysis; Intermediate Filament Proteins/*immunology; Mice; Mice, Inbred Strains; Rabbits; Rats; Scrapie/*immunology; Support, Non-U.S. Gov't
SP englisch
PO Japan