NR ALLX
AU Tateishi,J.; Sato,Y.; Nagara,H.; Boellaard,J.W.
TI Experimental transmission of human subacute spongiform encephalopathy to small rodents. IV. Positive transmission from a typical case of Gerstmann-Sträussler-Scheinker's disease.
QU Acta Neuropathologica 1984; 64(1): 85-8
PT journal article
AB Spongiform encephalopathy was transmitted to mice from a patient belonging to the "Sch" family with Gerstmann-Sträussler-Scheinker's disease (GSS). Incubation periods in the first passage were much shorter than those in mice infected with Creutzfeldt-Jakob disease. Clinical and pathologic findings of mice infected with both diseases were almost identical. This is the first successful transmission from a typical GSS case without severe spongiform change which suggests the possible transmissible nature of this disorder.
MH Animal; Brain/pathology; Cerebellar Ataxia/genetics/pathology/*transmission; Creutzfeldt-Jakob Syndrome/pathology; Dementia/*genetics/pathology; Human; Mice; Nerve Degeneration; Syndrome
SP englisch
PO Westdeutschland