NR AKUH
AU Shinagawa,M.; Muramatsu,Y.; Onodera,A.; Matsui,T.; Horiuchi,M.; Ishiguro,N.; Nakagawa,M.
TI Familial scrapie cases with shortened incubation periods
QU Journal of Veterinary Medical Science 1993 Aug; 55(4): 665-7
PT journal article
AB Two familial scrapie cases successively occurred in 29-month-old and 30-month-old Corriedale dams and in three of their offspring as early as 10-19 months of age in a small flock. They showed ataxy but no pruritus. Histopathological and immunochemical examinations of those sheep revealed vacuolation of nerve cells in brain tissue and presence of PrPsc, a component of scrapie-associated fibrils, in brain, spleen and lymph node tissues. We discuss about shortened incubation periods and lacking pruritus in the present scrapie cases.
MH Animal; Blotting, Western; Female; Male; Medulla Oblongata/pathology; Neurons/pathology; PrPsc Proteins; Prions/isolation & purification; Scrapie/*pathology/physiopathology/transmission; Sheep; Support, Non-U.S. Gov't
AD Department of Veterinary Public Health, School of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
SP englisch
PO Japan