NR AKKK
AU Sasaki,N.; Takeuchi,M.; Chowei,H.; Kikuchi,S.; Hayashi,Y.; Nakano,N.; Ikeda,H.; Yamagishi,S.; Kitamoto,T.; Saito,T.; Makita,Z.
TI Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques
QU Neuroscience Letters 2002 Jun 28; 326(2): 117-20
PT journal article
AB The objective of this study was to assess the pathological role of advanced glycation end products (AGE) and the receptor for AGE (RAGE) in Creutzfeldt-Jakob disease (CJD). We immunohistochemically investigated the occipital lobe of three patients with CJD containing with prion protein (PrP) plaques using anti-AGE and RAGE antibodies. Many PrP-positive plaques were observed in these patients, and the PrP-positive prion plaques also showed immunoreactivity for the anti-AGE antibody. Furthermore, many astrocytes contained-PrP positive granules, and the same astrocytes also contained many AGE- and RAGE-immunopositive granules. The staining pattern of these granules showed good concordance with that of PrP. These findings suggest that there may be a RAGE-mediated PrP degradation pathway in CJD as is the case for beta-amyloid protein in Alzheimer's disease.
MH Astrocytes/metabolism; Brain/*metabolism/*pathology; Creutzfeldt-Jakob Syndrome/*metabolism/*pathology; Cytoplasmic Granules/metabolism; Glycosylation End Products, Advanced/*metabolism; Human; Immunohistochemistry/methods; Occipital Lobe/metabolism/pathology; Prions/*metabolism; Receptors, Immunologic/*metabolism; Staining and Labeling; Support, Non-U.S. Gov't
AD Department of Neuropsychiatry, School of Medicine, Sapporo Medical University, S1W16, Chuo-ku, Sapporo 060-8543, Japan. nsasaki@sapmed.ac.jp
SP englisch
PO Irland