NR AKGY
AU Ryder,S.J.; Hawkins,S.A.C.; Dawson,M.; Wells,G.A.H.
TI The neuropathology of experimental bovine spongiform encephalopathy in the pig
QU Journal of Comparative Pathology 2000 Feb-Apr; 122(2-3): 131-43
PT journal article
AB In an experimental study of the transmissibility of BSE to the pig, seven of 10 pigs, infected at 1-2 weeks of age by multiple-route parenteral inoculation with a homogenate of bovine brain from natural BSE cases developed lesions typical of spongiform encephalopathy. The lesions consisted principally of severe neuropil vacuolation affecting most areas of the brain, but mainly the forebrain. In addition, some vacuolar change was identified in the rostral colliculi and hypothalamic areas of normal control pigs. PrP accumulations were detected immunocytochemically in the brains of BSE-infected animals. PrP accumulation was sparse in many areas and its density was not obviously related to the degree of vacuolation. The patterns of PrP immunolabelling in control pigs differed strikingly from those in the infected animals.
IN Mit Hirnhomogenat BSE-kranker Rinder wurden 10 erst 1-2 Wochen alte Ferkel parenteral inokuliert. Sieben der 10 Schweine entwickelten typische spongiforme Enzephalopathien. Immunhistochemisch wiesen sie in den Gehirnen dieser Schweine PrPsc nach.
MH Animal; Brain/metabolism/*pathology; Cattle; Encephalopathy, Bovine Spongiform/*transmission; Immunohistochemistry; Neurons/metabolism/pathology; Prion Diseases/pathology/transmission/veterinary; Prions/metabolism; Spinal Cord/metabolism/*pathology; Support, Non-U.S. Gov't; Swine
AD Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
SP englisch
PO England