NR AKGD
AU Ruffie,A.; Delasnerie-Laupretre,N.; Brandel,J.P.; Jaussent,I.; Dormont,D.; Laplanche,J.L.; Hauw,J.J.; Richardson,S.; Alperovitch,A.
TI [Incidence of Creutzfeldt-Jakob disease in France, 1992-1995]
OT Incidence de la maladie de Creutzfeldt-Jakob en France, 1992-1995
QU Revue d'Épidémiologie et de Santé Publique 1997 Dec; 45(6): 448-53
PT journal article
AB BACKGROUND: Recent developments in animal and humans transmissible spongiform encephalopathies have motivated a study on incidence and risk factors of Creutzfeldt-Jakob disease (CJD) in France and 4 other European countries. METHODS: CJD cases were ascertained through a national network including 250 neurological departments or neuropathological laboratories. CJD cases were classified as definite, probable or possible. Overall incidence rate and age-standardized incidence rates by department were computed. Standardized incidence ratios and their 95% confidence intervals were computed for comparing observed and expected number of CJD cases in each department. RESULTS: Between 1992 and 1995, 216 CJD cases were registered (mean incidence rate: 0.87 per million inhabitants). The distribution of CJD cases was heterogeneous (p < 0.007). Nevertheless, the distribution of standardized incidence ratios fitted quite well a Poisson distribution. The observed number of CJD cases was significantly higher than expected in 4 departments and lower in 1 department. CONCLUSION: Incidence of CJD in France is similar to that observed in other European countries. Analysis of distribution of CJD cases by department showed a few significant differences which can be due to random fluctuations.
ZR 11
MH Adult; Age Distribution; Aged; Aged, 80 and over; Creutzfeldt-Jakob Syndrome/classification/*epidemiology/transmission; English Abstract; Female; France/epidemiology; Human; Incidence; Male; Middle Age; Poisson Distribution; Population Surveillance; Registries; Risk Factors
AD INSERM Unite 360, Hopital de la Salpetriere, Paris.
SP französisch
PO Frankreich