NR AKEM
AU Rossini,P.M.; Caltagirone,C.; David,P.; Macchi,G.
TI Jakob-Creutzfeldt disease: analysis of EEG and evoked potentials under basal conditions and neuroactive drugs.
QU European Neurology 1979; 18(4): 269-79
PT clinical trial; journal article
AB EEG and evoked potential (EP) recordings of a female (aged 70) affected with Jakob-Creutzfeldt disease (JCD) are reported. A comparison of neurophysiological tests under basal conditions and pharmacological stimulation with methylphenidate, diazepam and piracetam was performed. Diazepam and methylphenidate produced a flattening of triphasic complexes and changes in background activity; piracetam did not seem to influence the abnormal brain bioelectrical environment. The authors conclude that EEG and EP abnormalities in JCD can be ascribed to two separate and interacting sources: (1) exaggerated massive excitatory input coming from a deep thalamic pace-maker throughout the diffuse projecting system, and (2) lack of inhibitory intracortical mechanisms.
MH Aged; Case Report; Cerebral Cortex/*physiopathology; Clinical Trials; Creutzfeldt-Jakob Syndrome/*diagnosis/physiopathology; Diazepam/administration & dosage/*diagnostic use; Electroencephalography; Evoked Potentials/drug effects; Human; Injections, Intravenous; Methylphenidate/administration & dosage/*diagnostic use; Piracetam/administration & dosage/*diagnostic use; Placebos; Pyrrolidinones/*diagnostic use
SP englisch
PO Schweiz