NR AKCW
AU Roikhel',V.M.; Fokina,G.I.; Mikhailova,G.R.; Lisak,V.M.; Sobolev,S.G.
TI [Cytomorphologic study of a line of hybrid somatic cells persistently infected with the scrapie agent]
OT Tsitomorfologicheskoe issledovanie linii gibridnykh somaticheskikh kletok, persistentno infitsirovannykh agentom skrepi
QU Tsitologiya i Genetika 1988 Jul-Aug; 22(4): 35-9
PT journal article
AB Virological, cytological and electron microscopic methods were used to study the peculiarities of the scrapie agent persistence in the tissue culture of the mouse and human hybrid cells. A long-term persistence of the scrapie agents in the cells (658 days) has been obtained. The fact of persistence is confirmed by the results of biotest and electron microscopic studies of the mouse CNS. The agent persistence promotes a decrease in the mitotic activity of the infected cells and development of the ultramicroscopic changes in cells similar to the picture of the specific changes in the CNS of mice inoculated by scrapie agent.
MH Animal; Brain/microbiology/ultrastructure; Cell Line; English Abstract; Human; Hybrid Cells/microbiology/*ultrastructure; Mice; Mice, Inbred BALB C; Microscopy, Electron; Mitosis; Prions/*pathogenicity; Scrapie/etiology/microbiology/*pathology; Time Factors
SP russisch
PO Sowjetunion