NR AJYD
AU Rey-Gayo,A.; Calbo Torrecilla,F.
TI [Protein structure: Folding and prions]
OT Estructura de proteinas: plegamiento y priones.
QU Enfermedades Infecciosas y Microbiologia Clinica 2002 Apr; 20(4): 161-7
ER Enferm Infecc Microbiol Clin 2002 Aug-Sep;20(7):315
PT journal article; review; review, tutorial
AB Transmissible spongiform encephalopathies have become a subject of prime social concern in recent years because of its relation to "mad cow disease" and their potential for transmission to humans. Among the most important scientific aspects of these diseases are the peculiar characteristics of the agent involved in their transmission. In this article we briefly describe the outstanding features of prions, the most widely accepted hypothesis for these diseases. We focus on the molecular characteristics of this protein, coded in the genome of the affected host, and describe the conformational alterations in the protein's tertiary structure that have been blamed for its pathologic activity. Our aim is to summarize the state-of-the-art knowledge on prions, the hypotheses proposed to explain mechanisms of disease transmission without agents containing genetic material, and some specific peculiarities of this new infectious agent. The links between this knowledge and possible therapeutic strategies to overcome the disease justify, once again, close interaction among chemistry, molecular biology, and medicine.
ZR 8
MH Animal; Cattle; Creutzfeldt-Jakob Syndrome/epidemiology/transmission; Encephalopathy, Bovine Spongiform/epidemiology; English Abstract; Human; Models, Biological; Models, Molecular; Phosphoprotein Phosphatase/chemistry/genetics; PrP 27-30 Protein/chemistry; PrPc Proteins/chemistry/genetics/pathogenicity; Prion Diseases/etiology/transmission/veterinary; Prions/*chemistry/genetics/pathogenicity; Protein Conformation; Protein Folding; Spain/epidemiology; Structure-Activity Relationship
AD Departamento de Quimica Fisica I. Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Spain. medprev@hch.sas.cica.es
SP spanisch
PO Spanien