NR AJOO
AU Powell-Jackson,J.D.; Weller,R.O.; Kennedy,P.; Preece,M.A.; Whitcombe,E.M.; Newsom-Davis,J.
TI Creutzfeldt-Jakob disease after administration of human growth hormone
QU Lancet 1985 Aug 3; 326(8449): 244-6
PT journal article
AB A 2-year-old girl had a craniopharyngioma removed in 1964. She received human growth hormone (HGH) twice a week from July, 1972, until July, 1976. In March, 1984, a subacute dementing illness developed with neurological signs that included pronounced cerebellar ataxia. A clinical diagnosis of Creutzfeldt-Jakob disease (CJD) was made. The patient died in February, 1985. Necropsy revealed a spongiform encephalopathy compatible with the transmissible form of CJD. HGH administration may be implicated in the transmission of the disease in this case.
IN Nach Entfernung eines Kopftumors im Jahr 1962 erhielt ein zum Zeitpunkt der Operation 2-jähriges britisches Mädchen von Juli 1972 bis Juli 1976 zweimal wöchentlich menschliches Wachstumshormon. Im März 1984 fielen eine zunehmende Demenz und Kleinhirnataxie auf. Im Februar 1985 starb die Patientin und die Diagnose Creutzfeldt-Jakob-Krankheit wurde histopathologisch bestätigt.
MH Case Report; Child, Preschool; Craniopharyngioma/drug therapy; Creutzfeldt-Jakob Syndrome/*chemically induced/pathology/physiopathology; Female; Growth Hormone/*adverse effects/therapeutic use; Human; Time Factors
AD John Powell-Jackson, Royal Hampshire County Hospital, Winchester, United Kingdom; Philip Kennedy, R.O.Weller, Southampton General Hospital, United Kingdom; M.A.Preece, Institute of Child Health, London WC1, United Kingdon; E.M.Whitcombe, John Newsom-Davis, National Hospital for Nervous Diseases, London WC1, United Kingdon
SP englisch
PO England