NR AJOC
AU Poser,C.M.
TI Notes on the history of the prion diseases. Part I.
QU Clinical Neurology and Neurosurgery 2002 Jan; 104(1): 1-9
PT historical article; journal article
AB The astute observation by William Hadlow, an American veterinary neuropathologist of the similarity between the histopathology of kuru, an obscure disease of the primitive tribe in New Guinea, and scrapie of sheep, was the first clue to the etiology of the transmissible spongiform encephalopathies (TSE). The knowledge that scrapie was transmissible but only after an unusually long incubation period, that the causative agent was highly resistant to heat and formalin, and that it seemed to be able to replicate in the absence of nucleic acid, eventually led to the discovery of the prion by Stanley Pruisner and the still controversial protein-only hypothesis of etiology of the TSE.
MH Animal; Disease Transmission/history; History of Medicine, 20th Cent.; Human; Kuru/diagnosis/history/transmission; Portraits; Prion Diseases/diagnosis/*history/therapy; Prions/history/physiology; Scrapie/diagnosis/history/transmission; Sheep
AD Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. cposer@caregroup.harvard.edu
SP englisch
PO Niederlande