NR AJNV
AU Porter,S.R.; Scully,C.; Ridgway,G.L.; Bell,J.
TI The human transmissible spongiform encephalopathies (TSEs): implications for dental practitioners.
QU British Dental Journal 2000 Apr 22; 188(8): 432-6
IA http://www.nature.com/bdj/journal/v188/n8/full/4800502a.html
KI Br Dent J. 2000 Jul 22;189(2):62. PMID: 10975153 Br Dent J. 2000 Nov 25;189(10):527. PMID: 11128253 Br Dent J. 2000 Sep 9;189(5):236. PMID: 11048382
PT journal article; review; review, tutorial
AB Transmissible spongiform encephalopathies (TSEs) are rare, fatal degenerative brain diseases which affect humans and certain animals, and are caused by inheritance or acquisition of prions (PrPs). Inherited TSEs include Fatal Familial Insomnia (FFI), Gerstmann-Sträussler-Scheinker syndrome (GSS) and other less well clinically characterised disorders, while the human infective TSEs include sporadic, iatrogenic and variant Creutzfeldt-Jakob disease (vCJD). The causative prions are found especially in neural tissues and spinal fluid, and in the case of vCJD, in lymphoreticular tissue. Available epidemiological evidence suggests that normal social or routine clinical contact with affected patients does not present a risk to health care workers, relatives or the community. Isolation of patients is not considered necessary. Nevertheless as the prions are resistant to conventional chemical, irradiation and heat sterilisation methods, highly specific cross-infection control measures are required for the dental management of patients with, or at notable risk, of TSE. The present article reviews current knowledge of the clinical consequences of prion disease and provides information regarding necessary changes to the cross-infection routine when managing patients infected, or at risk of, prion disease.
ZR 48
MH Animal; Cattle; Dental Disinfectants/pharmacology; Dental Instruments; Equipment Contamination/prevention & control; Human; *Infection Control, Dental; Prion Diseases/*prevention & control/transmission; Prions/drug effects; Risk Factors; Sheep; Sodium Hypochlorite/pharmacology; Sterilization/methods
AD Stephen Porter (S.Porter@eastman.ucl.ac.uk) (Professor of Oral Medicine), C. Scully (Dean and Professor of Special Needs Dentistry), Eastman Dental Institute for Oral Health Care Sciences, University College London, University of London, 256 Gray's Inn Road, London WC1X 8LD; G. L. Ridgway (Consultant Microbiologist, Infection Control), J. Bell (Clinical Nurse Specialist, Infection Control), Department of Clinical Microbiology, University College London Hospitals, Grafton Way, London WC1E 6DB
SP englisch
PO England