NR AJNF
AU Pollak,L.; Klein,C.; Giladi,R.; Kertesz,J.; Arlazoroff,A.
TI Progressive deterioration of brainstem auditory evoked potentials in Creutzfeldt-Jakob disease: clinical and electroencephalographic correlation.
QU Clinical Electroencephalography 1996 Apr; 27(2): 95-9
PT journal article
AB Brainstem auditory evoked potentials (BAEP) were recorded and correlated with the clinical and electroencephalographic (EEG) findings in three verified cases of Creutzfeldt-Jakob disease (CJD). In contrast to previous reports, there was progressive deterioration of the BAEPs, through initial asymmetry of wave latencies to abnormal wave morphology, and increased interpeak latencies. Consequently, in two of the patients, disorganization of the wave pattern and generalized conduction-time slowing appeared by the time there was a fully developed clinical picture of CJD with periodic EEG waves. In the third, clinically mild CJD, asymmetry of wave latencies in the BAEP emerged, correlating with the appearance of periodicity on EEG. Our findings are consistent with the late, progressive involvement of the brainstem by the pathological process in CJD.
ZR 24
MH Brain Death/physiopathology; Brain Stem/physiopathology; Case Report; Cerebral Cortex/physiopathology; Creutzfeldt-Jakob Syndrome/diagnosis/*physiopathology; Evoked Potentials, Auditory, Brain Stem/*physiology; Female; Follow-Up Studies; Human; Male; Middle Age; Neurologic Examination; Neuropsychological Tests
AD Department of Neurology, Assaf Harofeh Medical Center, Zerifin, Israel.
SP englisch
PO USA