NR AJMR
AU Pocchiari,M.; Masullo,C.; Lust,W.D.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Isonicotinic hydrazide causes seizures in scrapie-infected hamsters with shorter latency than in control animals: a possible GABAergic defect.
QU Brain Research 1985 Feb 4; 326(1): 117-23
PT journal article
AB Isonicotinic hydrazide, a drug that decreases the level of GABA, when injected subcutaneously in control and scrapie-infected hamsters induced tonic-clonic seizures in scrapie hamsters significantly earlier (P less than 0.0001) than in control animals. This suggests depression of the GABAergic system in scrapie-infected hamsters. To determine whether this lesion is pre or postsynaptic we measured the level of GABA, glutamate, cGMP and cAMP and the GABA-benzodiazepine receptor complex.
MH Animal; Brain/*physiopathology; Brain Chemistry; Convulsions/*chemically induced; Female; Glutamates/analysis; Glutamic Acid; Hamsters; Isoniazid/*pharmacology; Male; Mesocricetus; Scrapie/metabolism/*physiopathology; Sheep; Synaptic Transmission; gamma-Aminobutyric Acid/analysis/*physiology
SP englisch
PO Niederlande