NR AJHV
AU Payne,C.M.; Sibley,W.A.
TI Intranuclear inclusions in a case of Creutzfeldt-Jakob disease: an ultrastructural study.
QU Acta Neuropathologica 1975; 31(4): 353-61
PT journal article
AB Two types of intranuclear inclusions were described in a brain biopsy from a patient with Creutzfeldt-Jakob disease. The first type of intranculear inclusion was papova virus-like and was observed within 20% of the nuclei of all astrocytes and neurons examined. The particles measured 32 nm in diameter and consisted of a dense core surrounded by a multi-layered shell. The second type of intranuclear inculsion was a granulo-fibrillar nuclear body found within the nuclei of astrocytes and neurons. The possible significance of these inculsions to the etiology of Creutzfeldt-Jakob disease is discussed.
MH Astrocytes/microbiology; Cell Nucleus/microbiology; Creutzfeldt-Jakob Syndrome/*microbiology/pathology; Female; Helper Viruses/analysis; Human; *Inclusion Bodies, Viral; Microscopy, Electron; Middle Age; Neurons/microbiology; Papillomaviridae/analysis; Particle Size; Polyomaviridae
SP englisch
PO Westdeutschland