NR AJEQ
AU Paraf,A.
TI An immunological approach to prion diseases
QU Medical Hypotheses 1998 Jan; 50(1): 85-90
PT journal article
AB Ovine scrapie and bovine spongiform encephalopathy are genetic diseases, presenting probably autoimmunity transmissible by the oral route. The absence of immune response in prion diseases indicates a tolerant state for PrPc and PrPsc. The tolerant state against these diseases should be overcome before immunizing animals. We suggest that an early diagnosis may be possible using polyclonal and monoclonal antibodies specific for either ovine or bovine PrPsc. Such reagents could be obtained by immunizing corresponding animals with peptides from beta sheet molecules bound to a linker or with the complete molecule (27-30 kDa).
MH Animal; Antibodies, Monoclonal; Antibody Specificity; Autoimmunity; Cattle; Encephalopathy, Bovine Spongiform/diagnosis/genetics/immunology; Immune Tolerance; Models, Immunological; PrPc Proteins/immunology; PrPsc Proteins/immunology; Prion Diseases/genetics/*immunology; Prions/analysis/*immunology; Scrapie/diagnosis/genetics/immunology; Sheep
AD Institut National de la Recherche Agronomique, Pathologie Infectieuse Immunologie, Nouzilly, France.
SP englisch
PO England