NR AJDH
AU Özel,M.; Diringer,H.
TI Small virus-like structure in fractions from scrapie hamster brain
QU Lancet 1994 Apr 9; 343(8902): 894-5
PT journal article
AB The scrapie model in hamsters has been used to search for the agents that cause Creutzfeldt-Jakob disease in man and similar transmissible encephalopathies in animals. We found structures that are extraordinarily small for a virus, but exhibit viral structural properties in negatively stained samples, by electron microscopy in fractions containing scrapie-associated fibrils.
IN In scrapieinfizierten Hamstergehirnen wurden elektronenmikroskopisch Strukturen gefunden, die virale Struktureigenschaften besitzen sollen, obwohl sie für Viren extrem klein sind.
MH Animal; Brain/*microbiology/ultrastructure; Disease Models, Animal; Hamsters; Microscopy, Electron; Prion Diseases/microbiology/pathology; Scrapie/*microbiology/pathology; Support, Non-U.S. Gov't
AD Robert Koch-Institut des Bundesgesundheltsamtes, Berlin, FGR.
SP englisch
PO England
OR Prion-Krankheiten 6