NR AIZX
AU Ohgami,T.; Kitamoto,T.; Weidmann,A.; Beyreuther,K.; Tateishi,J.
TI Alzheimer's amyloid precursor protein-positive degenerative neurites exist even within kuru plaques not specific to Alzheimer's disease
QU American Journal of Pathology 1991 Dec; 139(6): 1245-50
PT journal article
AB To clarify the relationship between amyloid formation and amyloid precursor protein (APP), the brain sections from eight patients with Alzheimer's disease (AD) and four with Gerstmann-Sträussler Syndrome (GSS) were investigated immunohistochemically by the double-immunostaining method. In AD, most APP-positive senile plaques belong to classical plaques or primitive plaques, whereas in diffuse plaques, APP-positive neuritic components are rarely observed. The authors documented that anti-APP-labeled degenerative neurites surrounding kuru plaques in all four GSS patients. These kuru plaques were verified by double immunostaining using anti-prion protein and anti-APP. The APP-positive structures in kuru plaques were almost identical with those seen in the classical plaques in AD. The authors concluded that APP-positive degenerative neurites are not an early event in the amyloid formation of senile plaques. It is therefore postulated that depositions of beta/A4 and prion proteins are primary events that may involve the surrounding microenvironment and result in the secondary formation of APP-positive degenerative neurites, not specific to AD.
MH Alzheimer Disease/*metabolism/pathology; Amyloid beta-Protein/*metabolism; Amyloid beta-Protein Precursor; Gerstmann-Sträussler-Scheinker Disease/metabolism/pathology; Human; Immunohistochemistry; Kuru/*metabolism/pathology; *Nerve Degeneration; Neurites/*metabolism; Protein Precursors/*metabolism; Support, Non-U.S. Gov't
AD Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
SP englisch
PO USA