NR AISY
AU Namba,Y.; Tomonaga,M.; Kawasaki,H.; Otomo,E.; Ikeda,K.
TI Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
QU Brain Research 1991 Feb 8; 541(1): 163-6
PT journal article
AB During the course of our immunohistochemical studies on the change of lipids in Alzheimer's disease brains by using antibody to apolipoprotein E, a protein having a special relevance to nervous tissue, we unexpectedly found that apo E immunoreactivity was associated with amyloid in both senile plaques and cerebral vessels and neurofibrillary tangles. The immunoreactivity was also found in amyloid of kuru plaques in Creutzfeldt-Jakob disease. Pretreatment of the sections with formic acid greatly enhanced immunoreactivity of senile and kuru plaques to antibody to apo E.
IN In den amyloiden Strukturen bei Patienten mit der Alzheimer oder der Creutzfeldt-Jakob-Krankheit befindet sich auch Apolipoprotein E.
MH Alzheimer Disease/*metabolism/pathology; Amyloid/*metabolism; Apolipoproteins E/*metabolism; Brain/*metabolism; Creutzfeldt-Jakob Syndrome/*metabolism/pathology; Human; Immunohistochemistry; Kuru/metabolism/pathology; Neurofibrils/*metabolism/pathology; Support, Non-U.S. Gov't
AD Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan.
SP englisch
PO Niederlande