NR AIRS
AU Na,D.L.; Suh,C.K.; Choi,S.H.; Moon,H.S.; Seo,D.W.; Kim,S.E.; Na,D.G.; Adair,J.C.
TI Diffusion-weighted magnetic resonance imaging in probable Creutzfeldt-Jakob disease: a clinical-anatomic correlation.
QU Archives of Neurology 1999 Aug; 56(8): 951-7
PT journal article
AB BACKGROUND: Creutzfeldt-Jakob disease (CJD) is a rare transmissible disease that typically causes a rapidly progressive dementia and leads to death in less than 1 year. Although a few anecdotal reports suggest that diffusion-weighted magnetic resonance imaging may help substantiate premortem diagnosis of CJD, detailed correlation between radiographic data and clinical, electrophysiologic, and metabolic parameters is not available. METHODS: Signal abnormalities on diffusion-weighted images in 3 consecutive patients with probable CJD were correlated with psychometric features, electroencephalographic findings, and functional images with either positron emission tomography or single photon emission computed tomography. RESULTS: Focality of abnormalities on diffusion-weighted image, not apparent on routine magnetic resonance images, correlated closely with clinical manifestations of CJD. The topographic distribution of signal abnormality on diffusion-weighted image corresponded with abnormal metabolism or perfusion on positron emission and single photon emission computed tomographic scans. In 2 cases, the laterality of diffusion abnormalities correlated with periodic sharp wave activity on electroencephalograms. CONCLUSION: These findings extend previous observations that suggested a diagnostic and localizing utility of diffusion-weighted imaging in CJD.
MH Aged; Brain/pathology/radionuclide imaging; Case Report; Cognition Disorders/diagnosis; Creutzfeldt-Jakob Syndrome/*diagnosis; Disease Progression; Electroencephalography; Female; Human; Magnetic Resonance Imaging; Male; Middle Age; Neuropsychological Tests; Probability; Severity of Illness Index; Support, Non-U.S. Gov't; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon
AD Department of Neurology, College of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea.
SP englisch
PO USA