NR AINF
AU Monreal,J.; Collins,G.H.; Masters,C.L.; Fisher,C.M.; Kim,R.C.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Creutzfeldt-Jakob disease in an adolescent
QU Journal of the Neurological Sciences 1981 Nov-Dec; 52(2-3): 341-50
PT journal article
AB A 16-year-old boy was stricken with a progressive neurologic disorder characterized primarily by dementia progressing to severe neurologic debility in 12 months and death 28 months following the first symptoms. Pathologic examination showed a spongiform encephalopathy, consistent with a clinical diagnosis of Creutzfeldt-Jakob disease (CJD). The noteworthy features of the case are the age of onset, the somewhat prolonged course an the amount of white matter change. These are discussed within the frame of reference of CJD and the spongiform encephalopathies of infancy and childhood. Animal inoculation studies employing post-mortem embalmed brain as inoculum are currently in progress to determine the transmissibility of this patient's disease.
IN Ein 16-jähriger Junge starb 1978, 28 Monate nach den ersten Symptomen an der Creutzfeldt-Jakob-Krankheit.
MH Adolescent; Brain/*pathology; Case Report; Cerebral Cortex/pathology; Corpus Striatum/pathology; Creutzfeldt-Jakob Syndrome/diagnosis/*pathology; Follow-Up Studies; Human; Male
SP englisch
PO Niederlande