NR AIMR
AU Mohri,S.; Tateishi,J.
TI Host genetic control of incubation periods of Creutzfeldt-Jakob disease in mice
QU Journal of General Virology 1989 Jun; 70(6): 1391-400
PT journal article
AB Host genetic control of the incubation period of Creutzfeldt-Jakob disease (CJD) was studied using various inbred strains of mice, including B10 congenic strains. Various incubation periods were found in mice injected either intracerebrally or intraperitoneally with the Fukuoka 1 strain of the CJD agent; NZW/Sea and A/JJms had the shortest, and B10.AKM/Ola and C57BL/6J the longest, incubation periods. Length of the CJD incubation period did not correlate with the genetic markers tested, i.e. the murine major histocompatibility (H-2) complex (which has previously been reported to be linked to a gene influencing CJD incubation period in mice), coat colour or sex genes. In NZW/Sea x C57BL/6J F1 hybrid mice the CJD incubation periods were similar to that of the parent with the longest incubation period. Incubation periods of the backcross progeny from F1 and NZW/Sea were intermediate between those of the parental mice and had a unimodal distribution pattern. A similar observation was made on the progeny of the A/JJms x C57BL/6J mating. On the other hand, the length of incubation period for the NZW/Sea x B10.AKM/Ola F1 hybrid fell between those for the two parents and the NZW/Sea x A/JJms F1 hybrid had a significantly longer incubation period than those of the two parents. These results suggest that polygenes probably control the length of the CJD incubation period in mice.
IN Nach intrazerebraler oder intraperitonealer Inokulation mit dem Fukuoka-CJD-Stamm erkrankten Mäuse der Inzuchtstämme NZW/Sea und A/JJms mit den kürzesten, die Inzuchtstämme B10.AKM/Ola und C57BL/6J mit den längsten Inkubationszeiten. Es wurde aber kein Zusammenhang zwischen den Inkubationszeiten und dem Maus-MHC-Komplex oder dem Geschlecht der Empfängermäuse festgestellt.
MH Alleles; Animal; Brain/pathology; Comparative Study; Creutzfeldt-Jakob Syndrome/*genetics/pathology; Crosses, Genetic; Disease Susceptibility; Genes; Genetic Markers; H-2 Antigens/genetics; Hair Color/genetics; Linkage (Genetics); Mice; Mice, Inbred Strains; Time Factors
AD Laboratory Animal Center, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
SP englisch
PO England