NR AILI
AU Mittal,S.; Farmer,P.; Kalina,P.; Kingsley,P.B.; Halperin,J.
TI Correlation of diffusion-weighted magnetic resonance imaging with neuropathology in Creutzfeldt-Jakob disease
QU Archives of Neurology 2002 Jan; 59(1): 128-34
PT journal article
AB BACKGROUND: Although the diagnosis of Creutzfeldt-Jakob disease (CJD) is straightforward in fully developed cases, a definitive diagnosis can be difficult early in the course of the illness. T2-weighted magnetic resonance imaging (MRI) signal abnormalities, and recently, diffusion-weighted MRI abnormalities, have been described in patients with CJD, suggesting the utility of MRI in the early recognition of CJD. OBJECTIVE: To correlate diffusion-weighted MRI signal abnormalities with neuropathologic changes in CJD. MATERIALS AND METHODS: Diffusion-weighted MRI and neuropathologic changes of 2 patients with autopsy-proven CJD were examined in a blinded fashion by a neuroradiologist and a neuropathologist. RESULTS: Areas of bright signal on diffusion-weighted MRI correlated with a higher degree of spongiform changes. CONCLUSION: Diffusion-weighted MRI in CJD demonstrates specific-signal abnormalities that correlate well with areas of the most severe and characteristic neuropathologic changes.
MH Aged; Brain/pathology; Case Report; Creutzfeldt-Jakob Syndrome/*pathology; Fatal Outcome; Female; Human; *Magnetic Resonance Imaging; Male; Middle Age; Predictive Value of Tests
AD Department of Neurology, North Shore University Hospital, 300 Community Dr, Manhasset, NY 11030, USA
SP englisch
PO USA