NR AIKA
AU Minghetti,L.; Cardone,F.; Greco,A.; Puopolo,M.; Levi,G.; Green,A.J.E.; Knight,R.S.G.; Pocchiari,M.
TI Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease
QU Neurology 2002 Jan 8; 58(1): 127-9
PT journal article
AB The concentration of the cyclooxygenase product prostaglandin E(2) was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD.
AD Laboratory of Pathophysiology, Istituto Superiore di Sanita, Rome, Italy.
SP englisch
PO USA