NR AIJK
AU Millot,P.; Chatelain,J.C.; Baille,V.; Cathala,F.
TI [The OLA major histocompatibility complex of sheep. Genetic frequencies compared in Prelpe sheep with and without scrapie]
OT Le complexe majeur d'histocompatibilite OLA des ovins. Frequences geniques comparees chez des moutons Prealpes atteints ou non de tremblante (scrapie).
QU Comptes Rendus de l'Academie des Sciences. Serie III, Sciences de la Vie 1984; 298(11): 305-8
PT journal article
AB The OLA genic frequencies were studied in both normal "Prealpe" Sheep and those affected with Scrapie. In the non-affected Sheep of contaminated flocks, frequencies were generally decreased, compared with frequencies of the same factors in sick Sheep or in non-infected controls. Three OLA-A genes significantly decreased; at this locus, results in "Prealpe" and "Ile-de-France" Sheep were inversed. This observation excludes OLA genes being involved in pathogeny or resistance to the disease, but suggests the existence of a linkage between the OLA loci and at least one resistance or susceptibility locus.
MH Animal; English Abstract; *Gene Frequency; Immunity, Natural; *Major Histocompatibility Complex; Scrapie/*genetics/immunology; Sheep/*genetics/immunology; Support, Non-U.S. Gov't
SP französisch
PO Frankreich