NR AIHM
AU Merz,P.A.; Rohwer,R.G.; Kascsak,R.; Wisniewski,H.M.; Somerville,R.A.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Infection-specific particle from the unconventional slow virus diseases
QU Science 1984 Jul 27; 225(4660): 437-40
PT journal article
AB Scrapie-associated fibrils, first observed in brains of scrapie-infected mice, were also observed in scrapie-infected hamsters and monkeys, in humans with Creutzfeldt-Jakob disease, and in kuru-infected monkeys. These fibrils were not found in a comprehensive series of control brains from humans and animals affected with central nervous system disorders resulting in histopathologies, ultrastructural features, or disease symptoms similar to those of scrapie, kuru, and Creutzfeldt-Jakob disease. These fibrils are also found in preclinical scrapie and in the spleens of scrapie-infected mice; they are a specific marker for the "unconventional" slow virus diseases, and may be the etiological agent.
IN Scrapie-assoziierte Fibrillen wurden bei Creutzfeldt-Jakob-Patienten und experimentell infizierten Tieren in Gehirn und Milz und zumindest bei Mäusen auch schon präklinisch, jedoch nicht bei gesunden oder anderweitig erkrankten Menschen gefunden.
MH Alzheimer Disease/pathology; Amyloid/metabolism; Amyotrophic Lateral Sclerosis/pathology; Animal; Brain/drug effects/ultrastructure; Creutzfeldt-Jakob Syndrome/pathology; Cuprizone/pharmacology; Hamsters; Human; Kuru/pathology; Mice; Mice, Inbred C57BL; Parkinson Disease/pathology; Saimiri; Scrapie/pathology; Sheep; Slow Virus Diseases/*pathology; Spleen/ultrastructure; Support, U.S. Gov't, P.H.S.; Triethyltin Compounds/pharmacology
SP englisch
PO USA