NR AICW
AU Mayer,R.J.; Tipler,C.; Laszlo,L.; Arnold,J.E.; Lowe,J.; Landon,M.
TI Endosome-lysosomes and neurodegeneration
QU Biomedicine and Pharmacotherapy 1994; 48(7): 282-6
PT journal article; review; review, tutorial
AB A number of the major human and animal neurodegenerative diseases, such as Alzheimer's disease and sheep scrapie, are characterised by deposits of amyloid, arising through incomplete breakdown of membrane proteins. Although our knowledge concerning these diseases is increasing, they remain largely untreatable. Recently, attention has focussed on the mechanisms of production of different types of amyloid and the likely involvement within cells of acid compartments called endosome-lysosomes. These organelles may be 'bioreactor' sites for the unfolding and partial degradation of membrane proteins to generate the amyloid materials. These subsequently become expelled from the cell, or are released from dead cells, and accumulate as pathological entities. Common features of the disease processes give new direction to therapeutic intervention.
IN Die Autoren vermuten, dass die Umfaltung der Prionproteine in den sauren Endosom-Lysosomen stattfinden könnte. Die amyloiden Aggregate könnten dann aus den Zellen wieder ausgeschieden oder nach ihrem Absterben freigesetzt werden.
ZR 33
MH Alzheimer Disease/*metabolism/*physiopathology; Amyloid beta-Protein Precursor/metabolism; Animal; Endosomes/*metabolism; Human; Lysosomes/*metabolism; *Nerve Degeneration; Prions/metabolism
AD Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, UK
SP englisch
PO Frankreich