NR AIAY
AU Masullo,C.; Pocchiari,M.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Choline acetyltransferase activity and [3H]quinuclidinylbenzilate binding in brains of scrapie-infected hamsters
QU Neuroscience Letters 1984 Sep 28; 51(1): 87-92
PT journal article
AB Choline acetyltransferase (ChAT) activity and [3H]quinuclidinylbenzilate binding were studied in the brain of scrapie-infected hamsters and sham inoculated controls. Although scrapie-infected hamsters showed no reduction of ChAT activity compared to the controls, they showed a decrease in the affinity and maximum number of post-synaptic muscarinic receptors. Scrapie virus thus alters the cholinergic system at the post-synaptic rather than at the pre-synaptic level.
IN Bei scrapieinfizierten Hamstern wurde keine Änderung der Aktivität der Cholinacetyltransferase festgestellt. Hingegen zeigte eine veränderte Bindung von [3H]Quinuclidinylbenzilat eine Abnahme der Affinität und der maximalen Anzahl der postsynaptischen muscarinen Rezeptoren. Scrapie scheint demnach das cholinergec System eher postsynaptisch als präsynaptisch zu verändern.
MH Animal; Brain/enzymology/*metabolism; Choline O-Acetyltransferase/*metabolism; Comparative Study; Female; Hamsters; Mesocricetus; Parasympathetic Nervous System/physiopathology; Quinuclidines/*metabolism; Quinuclidinyl Benzilate/*metabolism; Scrapie/enzymology/*metabolism/physiopathology; Sheep; Synaptic Transmission; Tissue Distribution; Tritium/diagnostic use
SP englisch
PO Niederlande